Shz-1
- Product Name
- Shz-1
- CAS No.
- 326886-05-9
- Chemical Name
- Shz-1
- Synonyms
- Shz-1;(E)-N-(5-bromo-2-hydroxybenzylidene)benzenesulfonohydrazide;Benzenesulfonic acid [(5-bromo-2-hydroxyphenyl)methylene]hydrazide;2-[(5-BroMo-2-hydroxyphenyl)Methylene]hydrazide Benzenesulfonic Acid;Benzenesulfonic acid, 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide;sarcomeric tropomyosin,Shz 1,inhibit,cardiac-specific,Shz1,Inhibitor,Nkx2.5 expression,cardiogenic molecule,Shz-1
- CBNumber
- CB32677984
- Molecular Formula
- C13H11BrN2O3S
- Formula Weight
- 355.21
- MOL File
- 326886-05-9.mol
Shz-1 Property
- Boiling point:
- 503.9±60.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- pka
- 7.79±0.48(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 15211
- Product name
- Shz-1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 15211
- Product name
- Shz-1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 15211
- Product name
- Shz-1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 15211
- Product name
- Shz-1
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $595
- Updated
- 2024/03/01
- Product number
- B685180
- Product name
- 2-[(5-Bromo-2-hydroxyphenyl)methylene]hydrazideBenzenesulfonicAcid
- Packaging
- 25mg
- Price
- $265
- Updated
- 2021/12/16
Shz-1 Chemical Properties,Usage,Production
Description
SHZ-1 (326886-05-9) triggers cardiac mRNA and protein expression in a variety of embryonic and adult stem/progenitor cells including human mobilized peripheral blood mononuclear cells (M-PBMC).1?A lead compound for the discovery of drugs which promote myocardial repair/regeneration by activating cardiac differentiation in M-PBMC. Cell permeable.
Uses
2-[(5-Bromo-2-hydroxyphenyl)methylene]hydrazide Benzenesulfonic Acid, is a sulfonylhydrazone that activates cardiac differentiation, inducing the expression of early cardiac genes in mouse pluripotent and embryonic stem cells in vitro at low micromolar concentrations.
References
1) Sadek?et al. (2008),?Cardiogenic small molecules that enhanced myocardial repair by stem cells; Proc. Natl. Acad. Sci. USA,?105?6063